Liver microsome liver microsomes are by far the most widely used in vitro model providing an affordable way to give a good indication of the cyp and udp glucuronyltransferases ugt involved in the metabolism of a drug2. The tertiary amines are oxidized only to the amine oxide secondary amines are oxidatively n dealkylated at least in part the oxidase does not catalyze the oxidation of n methyl substituted amides carbamates or heterocyclic nitrogen compounds containing a polar group or to the amino group microsomes and drug oxidations documents . Microsomes and drug oxidations is a record of the proceedings of the third international symposium on microsomes and drug oxidations held in berlin germany in july 1976 the compendium provides an overview of knowledge on the oxidative metabolism of drugs carcinogens and various other environmental chemicals. Then the activities of fmo3 variants in human liver microsomes and the activities of recombinantly expressed fmo3 variant proteins with respect to the oxygenation of nitrogen and sulfur containing drugs were summarized and the potential for drug interactions was demonstrated
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