Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension new findings for an old problem jeremy pt ward 1 and ivan f mcmurtry 2 1 kings college london division of asthma allergy and lung biology london se1 9rt uk. Hypoxic pulmonary vasoconstriction hpv is a homeostatic mechanism that is intrinsic to the pulmonary vasculature intrapulmonary arteries constrict in response to alveolar hypoxia diverting blood to better oxygenated lung segments thereby optimizing ventilation perfusion matching and systemic oxygen delivery. Hypoxic pulmonary vasoconstriction and the diffusing capacity in pulmonary hypertension secondary to idiopathic pulmonary fibrosis it was hypothesized that janus kinase 2 plays a critical role in the vasoconstriction of pas in patients with ipf the janus kinase 2 expression in the pas may also predict the magnitude of vasoconstrictive . Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization article pdf available in cardiovascular research 993404 411 may 2013
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